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She says several companies, including her own, are developing small-molecule TREM2 agonists that can turn up the volume on microglia, but only where amyloid or another misfolded protein or target is found

Animal models, especially gene knockout and transgenic models, have played an indispensable role in mechanistic verification, confirming the causal relationship between key inflammatory mediators (e.g., TNF-) and testicular-penile damage in preclinical settings, and providing a preclinical platform for evaluating the efficacy of potential therapeutic agents (210)

Neuroscience (2008) 156:56379

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