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4 Circadian rhythms regulate post-IS BBB repair via immune system modulation 4.1 Circadian rhythms orchestrate immune cell-mediated BBB repair following IS After stroke, BBB dysfunction involves several inflammatory mechanisms, including increased matrix metalloproteinases (MMP-2/9), excessive ROS production, polarization of microglia toward pro-inflammatory states, and infiltration of peripheral leukocytes (8891)

doi: 10.1007/s00705-006-0880-2 85 ZhangK.ShenY.WangT.WangY.XueS.LuanH.et al

These findings position neutrophil ferroptosisorchestrated by GPX4as a mechanistic bridge between iron dyshomeostasis and loss of self-tolerance in SLE, offering a rationale for therapeutic strategies targeting neutrophil redox resilience or iron chelation in autoimmune disease

GRB2, a HER2 adaptor protein, binds BECN1 to inhibit autophagy by suppressing VPS34 activity 38

Helene H Hansen Duus and Katrine Kirkeby were responsible for the statistical analyses