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Recent studies have elucidated the molecular mechanisms underlying these interactions, highlighting their roles in tumor immune evasion and progression across cancers

This double layer of epithelium is composed of a pigmented epithelium (PE), which interfaces with the highly vascularized stromal tissue that contains fenestrated capillaries, and a non-pigmented epithelium (NPE) which interfaces with the aqueous humor [73]

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Pecinova A, Drahota Z, Kovalcikova J, Kovarova N, Pecina P, Alan L, Zima M, Houstek J, Mracek T (2017) Pleiotropic effects of biguanides on mitochondrial reactive oxygen species production