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Age-related reductions in reproductive hormone levels, testicular function, chromosomal integrity, and sperm health, as well as increased oxidative stress and cumulative damage to sperm DNA, all contribute to reduced fertility

Human evidence - Phase 2 type 2 diabetes (Rosenstock et al., Lancet 2023) Adults with type 2 diabetes, 36 weeks

Smart, N., Risebro, C

The MOTS-C Connection MOTS-C activates AMPK through a mitochondrial stress pathway, improving fat oxidation and cellular energy efficiency

The association between coffee intake and the urinary concentrations of 8-hydroxydeoxyguanosine (8-OHdG), a biomarker of systemic oxidative damage and DNA repair, was analyzed: by examining more than 200 female subjects, the data showed that the urinary concentrations of 8-OHdG tended to decrease in women with a daily intake of 23 cups of coffee