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Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis/chronic fatigue syndrome: A systematic review and meta-analysis

The correct C rating depends on the model and what you actually expect from it

The responsible framing is that the barrier and the immune system are intimately linked, that permeability is a plausible and partly validated contributor, and that the full causal picture is still being worked out

However, these findings have not been observed in human studies, and the clinical relevance remains uncertain

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