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The compound exists in both reduced (GSH) and oxidized (GSSG) forms, with the reduced form being the active antioxidant state

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[22] In living organisms, one-carbon units in a variety of oxidation states may be attached to the N 5 nitrogen atom of the pteridine ring and/or the N 10 nitrogen atom of the p-aminobenzoyl group of tetrahydrofolate

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The decline in oestrogen appears to remove a layer of protection, which in turn accelerates depletion of this critical molecule, creating a cycle that worsens symptoms