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Summary Keywords thiamine, gastrointestinal beriberi, acetylcholine, intestinal ThDP-dependent enzymes, intestinal transport of thiamine, intestinal metabolism of thiamine, functional gastrointestinal disorder Citation Overton E, Emelyanova A and Bunik VI (2025) Thiamine, gastrointestinal beriberi and acetylcholine signaling

Kim YJ, Lee SH, Jeon SM, Silwal P, Seo JY, Hanh BTB, Park JW, Whang J, Lee MJ, Heo JY, et al

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In a double-blind, randomized, clinical trial, a group of sickle cell anemia patients receiving hydroxycarbamide experienced significantly less pain and required fewer blood transfusions than those receiving placebo (Charache 1995)

This means the topical evidence, while real, is itself of modest strength