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An earlier and arguably more influential paper from three Indian dermatologists, published in the Indian Journal of Dermatology, Venereology and Leprology , identified three randomised controlled trials supporting a skin-lightening effect and a good safety profile for topical and oral glutathione specifically

By using Western blot, immunofluorescence and other techniques, the expression and distribution of tight junction proteins were analyzed, and the effect of IGF-1 LR3 on barrier integrity was studied

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doi: 10.1038/352168a0