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The Reviews Highlights The term brain fatigue, introduced in medicine by [5,6,7], refers to long-lasting mental fatigue after stroke, traumatic or infectious brain injury, or aging low-grade neuroinflammation of the central nervous system

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Extrapolation of these doses to humans, using standard allometric conversion factors (factor of 6.2 for rats), yields theoretical doses on the order of 1.6 g/kg in humans