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Cagrilintide trials have shown weight loss results of roughly 2023% in certain combination study arms, making it one of the most closely studied amylin receptor agonists in current clinical investigation

4.4.3 Bumetanide Bumetanide is a highly effective loop diuretic that acts by inhibiting NKCC1 and NKCC2, thereby reducing intracellular Cl - concentrations and shifting the action of GABA from excitation to inhibition

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In limited data it's generally reported as well-tolerated, but human safety data is still limited and long-term effects aren't fully characterized