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NNMT is overexpressed in adipose tissue and various cancer cell lines, and its inhibition has been studied as a strategy to increase intracellular NAD+ levels, enhance one-carbon metabolism, and reduce adipogenesis in preclinical models

Thioredoxin-1 regulates IRE1alpha to ameliorate sepsis-induced NLRP3 inflammasome activation and oxidative stress in Raw 264.7 cell

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