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The gpoA mutant exhibited diminished survival across multiple organs relative to the wild-type strain, suggesting that GpoA contributes to pneumococcal pathogenesis

Journal of the American Society of Nephrology: JASN , 21 (2), 212222

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The novelty of this review lies in its integrative approach, moving beyond a mere description of disparate pathways to synthesize a coherent framework that connects key metabolic nodessuch as the mammalian target of rapamycin (mTOR)-hypoxia-inducible factor 1-alpha (HIF-1)-glycolysis axis, AMP-activated protein kinase (AMPK)-FAO signalinginto a dynamic immunometabolic network ( Figure 1 )

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