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The risk groups remain consistent: people eating plant-based or low-meat diets, adults over 50, long-term users of metformin or proton pump inhibitors, anyone with GI absorption issues, people on GLP-1 protocols with significantly reduced food intake, and heavy alcohol users

Depression or Suicidal Thoughts: Rare, but critical to monitor, especially in individuals with pre-existing mood disorders

Nusse R, Clevers H (2017) Wnt/-catenin signaling, disease, and emerging therapeutic modalities

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Milk thistle is also indicated for liver problems that may occur in relation to medicines, chemical exposure or environmental pollutants (1)