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instead, research points to interactions with the nitric oxide (NO) system, growth factor receptor upregulation, and modulation of several cytokine pathways

As shown in Figure S7, key differences in the binding modes of non-cyclic ligand 7a and cyclic ligands 7b 7i were revealed through analysis of their intermolecular interaction profiles, with 7a forming numerous but low-frequency contacts - likely due to its flexible warhead - while the more rigid cyclic ligands engaged in fewer but higher-frequency interactions, indicating slightly greater binding specificity and complex stability

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World J Gastroenterol 20:1775617772

Protective effects of grape seed extract fractions with different degrees of polymerisation on blood glucose, lipids and hepatic oxidative stress in diabetic rats