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and (d) lymphopenia and reduced T cell proliferation, affecting Th and cytotoxic (Tc) cells [147,148,149,150] resulting from: (i) impaired de novo production of new nave T cells due to accelerated aging and thymic atrophy, (ii) reduction of the memory T cell subset due to spleen sequestration and cell consumption associated with, among other factors, increased apoptosis, and (iii) impaired compensatory peripheral proliferation [151,152,153,154]

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