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While blood flow and vascular transport of nutrients may play a role in heat-enhanced limb elongation (discussed in section 6), temperature may also directly alter growth through changes in IGF-1 expression

Finally, degradation/release pathways depict the release mechanism, where PLGA nanoparticles degrade under high GSH conditions, releasing the drug to exert its therapeutic effect selectively within tumor cells

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The researchers of that last study acknowledge that the number of controlled human studies into liposomal glutathione remains limited

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