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DATA AND SOFTWARE AVAILABILITY The RNA-Seq data obtained in this study has been uploaded to NCBI GEO datasets, under accession number GSE94395 ( The software to analyze the data is available at Supplementary Material Highlights

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Furthermore, pristine SiO 2 NPs, which could not be taken up by erythrocytes, were shown to promote ROS-mediated and caspase-3-dependent eryptosis [452] (Fig