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Oxidative damage in neurodegeneration: roles in the pathogenesis and progression of Alzheimer disease

An extension of this concept is that different agonists could also lead to different mechanisms of desensitization, as each agonist-induced GPCR conformation could possess different affinities for regulatory proteins such as the GRKs or arrestins

Polymorphisms of some genes involved in the regulation of ROS production are associated with hypertension, suggesting their potential influence on blood pressure control and response to antihypertensive medication

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Day JW, Chiriboga CA, Crawford TO, Darras BT, Finkel RS, Connolly AM, et al