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Symptoms of glutathione deficiency may vary from person to person

Potential concerns include appetite stimulation, which may counteract weight-loss goals, and ghrelin-mediated effects on cortisol and sleep

The identification and understanding of these factors will open new avenues for the development of therapeutic strategies

For ethical and financial reasons, there is a preference to minimize in vivo investigations to elucidate such behavior, but for subcutaneously administered drugs there is the added complication that correlations between animal models and human outcomes tend to be particularly poor

Larger trials are needed to ensure that curcumin can be safely used with conventional UC treatments and to further support its potential therapeutic benefits for relapsing-remitting UC