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Riboflavin status, measured by the functional biomarker erythrocyte glutathione reductase coefficient (EGRac), has been found to decrease only marginally, up to 10 % during pregnancy, however this was reported to occur together with a progressive increase in the prevalence of riboflavin deficiency, especially towards the end of the third trimester (Reference Heller, Salkeld and Krner63Reference Bates, Prentice and Paul65)

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-KG deficiency blocks AMPK translation As an energy sensor, AMPK inhibits fatty acid synthesis and promotes FAO and mitochondrial metabolism to supply malate and isocitrate for NADPH homeostasis 26

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