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*Correspondence: Xavier Kammerscheit, [email protected] Cassier-Chauvat, [email protected] This article was submitted to Microbial Physiology and Metabolism, a section of the journal Frontiers in Microbiology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Environmental stressors further modulated susceptibility: high ammonia levels damaged mucosal barriers and impaired tight junctions 107 , while thermal stress activated the hypothalamicpituitaryadrenal axis, inducing stress-related immunosuppression and weakening respiratory mucosal defense 108

Tumors exhibiting SDH mutations are more aggressive and usually proliferate at a much faster rate than normal cells [9]