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Suppresses Tumor Growth: Inhibits tumor cell proliferation and induces cell death

However, the studies mentioned above highlight its significance in AS and offer new insights for investigating the pathological mechanisms of AS through ferroptosis

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Interestingly, the insulin/IGF-1 pathway displays an antagonistic pleiotropy with aging, i.e., during development insulin/IGF-1 signaling has fundamental functions in cellular differentiation and the growth of animals, whereas later in the life, it regulates metabolism but its activity clearly accelerates the aging process [1, 2]

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