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This upregulation promotes the interaction between HRD1 and NRF2, inducing the ubiquitination and degradation of NRF2

As early as 1998, cytochrome P450 was introduced within HSV-I, enabling conversion processes whereby cyclophosphamide becomes activated specifically inside malignant tissues, leading toward notable anticancer effects evidenced across medulloblastoma atypical teratoid/rhabdomyosarcoma brain neoplasms among others (105, 106)

Genipin increases oxaliplatin-induced cell death through autophagy in gastric cancer

We are currently testing other shelterins and other antioxidants to find the most potent one for potential translation, but I'd say the outlook is quite promising for this technology

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