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Extracellular nucleosomes and NET-bound histones provide negatively charged surfaces that can activate the contact pathway via factor XII (FXII) autoactivation, while NET-associated tissue factor (TF) and TF-bearing microparticles amplify extrinsic pathway signaling in certain inflammatory contexts [64]

mean and p values indicated, unpaired (two-sided) t-test

Ferroptosis and specific vascular diseases Ferroptosis in VSMCs is intricately associated with multiple cellular processes, including cell death, senescence, and proliferation

4), and more distal leaves showed [Ca 2+ ] cyt propagation with the increased GSH concentrations (Supplementary Fig

These findings suggest that melatonin supplementation may improve IVF-FET outcomes in women of advanced maternal age by modulating cuproptosis and ferroptosis pathways and enhancing mitochondrial function, potentially offering a promising adjuvant therapy for improving IVF success rates in older women