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Lactate accumulation in synovial fluid is caused by the high metabolic demand of synovial cells in RA patients 48

These LL-37/DNA complexes are potent activators of plasmacytoid dendritic cells, triggering massive production of type I interferons, the same cytokines that drive the "interferon signature" characteristic of active lupus

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311 In addition to the excessively increased consumption of NAD + , multiple viruses cause a decline in NAD + concentration through reducing the protein levels of crucial enzymes in the NAD + biosynthesis pathway, including QPRT and NAMPT

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