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This PERK activation triggers the Akt/p21 pathway, inducing cellular senescence and diminishing regenerative capacity (55)

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By suppressing TGF-1 expression and preventing Smad2/3 phosphorylation, luteolin downregulates core ECM components, such as collagen I, fibronectin, and alpha-smooth muscle actin (-SMA), thereby limiting myofibroblast activation and pathological ECM accumulation

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Glutathione plays a vital role in protecting brain cells from oxidative stress, which is linked to cognitive decline