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Rotation also prevents ordinary local irritation, bruising, and micro-scarring from concentrating in one area, and it keeps each zone healthy and usable across a multi-week protocol

PMID: 34200752 Biochem Biophys Rep Histone H3 lysine-trimethylation markers are decreased by recombinant methioninase and increased by methotrexate at concentrations which inhibit methionine-addicted osteosarcoma cell proliferation

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Br Med J 282:258, 1981