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Theres no scientific evidence supporting the need for colon cleansing in healthy individuals, and these practices can actually disrupt the beneficial bacteria in your gut and potentially lead to electrolyte imbalances

Costa DL, Diniz JB, Requena G, Joaquim MA, Pittenger C, Bloch MH, et al

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As mucosal taste cells, EECs not only act on adjacent intestinal epithelial cells through paracrine but also activate receptors in the enteric nervous system, vagus nerve, and spinal cord afferent pathways, playing a key role in the information transmission between the intestinal and nervous systems (9)

Microbe-associated molecular patterns (MAMPs) are molecules found on bacterial surfaces (203) which interact with the immune cell receptors of the host to promote inflammation (204)