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These kinases phosphorylate the membrane transporters (DAT, NET, SERT), leading to two outcomes: the transporters are either internalized into the cell (ceasing all reuptake function) or they undergo a conformational shift that causes them to operate in reverse

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Chronic reduction of dietary energy intake without malnutrition decreases adiposity, inflammation and improves metabolic profiles (3,4)

Weight loss is generally the first-line treatment consideration for women with polycystic ovary syndrome who are overweight

USA 112 , E2245E2252 (2015)