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10.1126/science.7909170 Science 252 WicknerR

FDA described insufficient clinical safety information, characterisation concerns and inadequate evidence of effectiveness for its reviewed use

Dietary intake: Vegetarians, vegans, and those who limit their daily consumption of animal products may have to consume more vitamin B12, as it is mainly present in foods of animal origin

The mechanism involves TGF-beta 1, a marker we measure in Chronic Inflammatory Response Syndrome (CIRS)

High-dose oral supplements (often 10002000 micrograms daily) or intramuscular injections (typically 1mg hydroxocobalamin) used to treat pernicious anaemia or deficiency states can temporarily elevate serum levels