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Effects of the MTHFR Mutation: Reduced Folate Metabolism: Folate (vitamin B9) is essential for many processes in the body, and MTHFR mutations can hinder the conversion of folate to its active form (5-MTHF)

Furthermore, the incidence of grade 3 or higher TRAEs was 25.6% among those who received dato-DXd vs 42.1% in patients who received paclitaxel in TROPION-Lung01

That said, responsible use requires medical supervision

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