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ENT-01 ( squalamine phosphate ) inhibits -synuclein aggregation in the gastrointestinal tract and significantly increased the number of complete spontaneous bowel movements per week after 25 days on ENT-01 treatment in a double-blind, placebo-controlled, phase 2b RCT in 150 participants with PD and constipation however at the expense of gastrointestinal AEs in up to one third of participants [166]

This mechanism makes Dihexa a valuable tool for studies of HGF/c-Met pharmacology, growth factor signaling, and receptor-associated regulatory networks

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doi: 10.1007/s11745-004-1305-4

If running 4-6 week protocols, 50mg may provide exactly what you need without excess