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We found that short-term, high-level exposure leads to pronounced changes in the metabolism of the cells, most notably a shift away from fatty acid synthesis towards glycolysis and lactate production

doi: 10.1080/19490976.2024.2426617 96 JiaL.JiangY.WuL.FuJ.DuJ.LuoZ.et al

This process, along with GCL inhibition and the formation of mixed disulfides between GSH and protein sulfhydryl, concurred to a steady-state decrement of free GSH concentration and, consequently, to an intracellular redox state shift toward more oxidizing conditions, which could be required for avoiding fast reduction of oxidized cysteines allowing the upstream ROS-induced autophagic stimulus to be propagated

& Wuthrich, K

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