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Based on proximity labeling and co-immunoprecipitation, seven E3 ubiquitin ligases were identified as potential interactors of NHR-49, with the top candidates being the HECT domain-containing E3 ligase, HECD-1, with 30 PSMs detected via proximity labeling, and the WW domain-containing E3 ligase, WWP-1, with 110 PSMs identified through co-immunoprecipitation (Supplementary Fig

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doi: 10.1152/physrev.2001.81.2.629

UK clinical guidelines explicitly recommend cyanocobalamin as a safe, cost-effective form of B12, though other chemical forms like methylcobalamin are also effective [12] [13]

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