glutathione ovarian cancer Isoliquiritigenin-Loaded Platinum(IV) Prodrug Micelles Induce Sustained Endoplasmic Reticulum Stress for Promoting Cisplatin Chemosensitivity in Rictor orchestrates β-catenin/FOXO balance by

Previous studies have shown that the mechanism by which chemotherapy drugs induce tumor cell death primarily involves the promotion of ROS production [14]

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Pro-apoptotic elements, BCL2 associated X, apoptosis regulator (BAX) and BCL2 antagonist/killer 1 (BAK1), drive processes such as mitochondrial outer membrane permeabilization and the creation of the mitochondrial permeability transition pore (MPTP), thus regulating the formation of pores in the outer mitochondrial membrane [112]

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