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Nicotinamide Adenine Dinucleotide (NAD+) is a coenzyme essential for cellular energy production and DNA repair

Based on preclinical (animal and cellular) data only, inhibition of NNMT by 5-Amino-1MQ is theorised to: Raise intracellular NAD+ levels Activate SIRT1 and other sirtuins (proteins linked to metabolic regulation) Reduce fat cell (adipocyte) size and proliferation Improve insulin sensitivity These effects have been demonstrated in mouse models (Neelakantan et al., 2019), but robust human clinical trial data are currently absent

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Therefore, researchers are actively investigating the potential of NNMT inhibitors such as 5-amino-1MQ in experimental models

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