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As a water-soluble vitamin, excess B12 is excreted in urine, and no upper limit has been set in the UK due to its low toxicity

Tested by independent laboratories for heavy metals, residual solvents, and endotoxins, in line with established limits

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Additional Info Human Metabolome Database Harvard School of Public Health Johns Hopkins Medicine Harvard Health Publishing

For opened multi-dose vials without a different manufacturer date, CDC summarizes USP guidance as 28 days after first puncture. What refrigeration is required for reconstituted peptides