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Furthermore, pretreatment with free lactoferrin reduced this uptake, confirming lactoferrin receptor-mediated endocytosis

doi: 10.1210/jcem-61-4-618 109 HoKYVeldhuisJDJohnsonMLFurlanettoREvansWSAlbertiKGet al

PubMed Zlokovic BV, Susic VT, Davson H, et al

It should be noted that an NADH-bound Mt DHDPR structure showed a partially closed conformation, with the authors speculating that this unexpected closed structure might represent a snapshot of the equilibrium state between open and closed forms awaiting further substrate binding, and that subsequent substrate binding might induce the fully closed conformation 21

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