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What the evidence is preclinical actually means for a reader Preclinical means the findings come from cell cultures and animal models, not from controlled human trials

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Moreover, prospective observational data from bariatric surgery (SOS study) suggest that 15% mean WL and weight maintenance over a period of 15 years in people with T2D and obesity could lead not only in long-term diabetes remission for a significant proportion of them (around 30%), but also in reduction of micro- and macrovascular complications compared to the control group [10,11]