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Antioxidant treatment in male mice prevents mitochondrial and synaptic changes in an NMDA receptor dysfunction model of schizophrenia

With advancing age, mitochondrial function deteriorates, characterized by increased ROS production, accumulation of mitochondrial DNA (mtDNA) mutations, altered mitochondrial dynamics, a decline in the mitochondrial unfolded protein response (UPRmt), and reduced respiratory chain activity (Sun et al., 2023) Additionally, AS-IV reduces ROS overproduction and mitochondrial dysfunction induced by angiotensin II (Ang II), thereby inhibiting vascular smooth muscle cell senescence (Lu Y

They noted that the natural peptide has protective functions in the gut

In addition to direct neutralization of fungi and their antigens, antibodies can inhibit fungal growth, modify gene expression, signaling and lipid metabolism, induce iron starvation, and reduce polysaccharide release and biofilm formation [6, 24]