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This question has gained attention as research explores effects beyond this medication's FDA-approved uses for type 2 diabetes and weight management

10.2174/13816128113190990411 78 SikiricP.SeiwerthS.RucmanR.TurkovicB.RokotovD

This interaction was mapped at the hydrophobic domain of G0S2 and the patatin-like domain of PNPLA2, whereby overexpression of G0S2 diminished adipocyte lipolysis, and deletion increased both basal and stimulated lipolysis (52)

The bottom line on safety: The TRAVERSE trial (2023) the largest cardiovascular safety trial of TRT to date, with 5,204 men followed for a mean of 33 months found no increased risk of major adverse cardiac events at therapeutic doses

doi:10.1080/10408398.2018.1511967 Calderon-Ospina CA, Nava-Mesa MO