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A straight laser Doppler probe (outer diameter: 0.9 mm) was directed to the papilla between the two upper incisal teeth using manipulator fixation

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Professor Muresanus research contributions include: Principal investigator for the CARS trial (Cerebrolysin and Recovery After Stroke), the largest randomized controlled trial examining functional outcomes Lead investigator for CAPTAIN trials evaluating Cerebrolysin in traumatic brain injury populations Extensive research on neurotrophic factor signaling and neuroprotective mechanisms Development of multimodal therapeutic strategies combining Cerebrolysin with rehabilitation Investigations of dose-response relationships and optimal treatment protocols across neurological conditions His work has been instrumental in advancing understanding of peptidergic neuroprotection, though clinical translation challenges remain a focus of ongoing investigation

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Risk factors that increase susceptibility include pre-existing liver conditions, alcohol consumption, and concurrent use of retinoid medications such as isotretinoin