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2003 Oxidative damage of the macromolecules increases with age and has been suggested to contribute importantly to the aging process and the pathogenesis of many age-related diseases

500 Additionally, PepGens PGN-EDO51, designed to skip exon 51 in the DMD gene, has shown promising results in Phase I clinical trials and is now in Phase II (NCT06079736)

Product inhibition and energy state also controls the TCA flux

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We found that autophagy is activated in RGCs, and possibly also in displaced amacrine cells, in EAAC1 and GLAST KO mice, and NAC treatment suppresses autophagy only in EAAC1 KO mice