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Muraoka, M., Ohno, M., Nakai, T., Matsuura, H., Nagano, K., Arai, M., Hirata, Y., Uyama, H., & Hirata, K

Inhibition of LDHA decreases the inflammatory response induced by bTNF- in bFLS As previously demonstrated, bTNF- increases the expression of LDHA, an enzyme that converts pyruvate to lactate with the production of NAD +

Dihexa (PNB-0408, N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) is a synthetic angiotensin IV analogue designed as a potent activator of neurotrophic signalling

Subcellular compartmentalization of NAD(+) and its role in cancer: a sereNADe of metabolic melodies

Importantly, a clinical study has demonstrated that combining radiotherapy with higher doses of the TGF-blocking antibody fresolimumab (10 mg/kg) increases overall survival significantly in metastatic breast cancer patients compared to those undergoing radiotherapy and receiving lower doses of fresolimumab (1 mg/kg) [135]