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Interestingly, when FOXO4 expression was silenced in TM3 cells using siRNA prior to H2O2 treatment, cell viability decreased, and apoptosis increased, despite elevated p53 levels

85 The main scar-forming cells in the CNS are perivascular fibroblasts 89 and type A pericytes, 90 which produce the fibrotic extracellular matrix that cements the scar

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