Elesclomol is widely recognized to induce copper overdose and cell death (139), by acting as a copper ion carrier with a hydrophilic pore in its centre, to which Cu2+ ions can bind easily, facilitating copper entry into cells, thus increasing the intracellular copper concentration (140), and this, in-turn increases ROS levels, triggering oxidative stress (141) and ultimately cell death
Ladin, D
It does not make the physician's step optional
Poster Session II - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION 06.00 - NOVEL TARGET/ EXPERIMENTAL FIDINGS TO CLINICAL TRANSLATION - 06.01 - PATHOPHYSIOLOGY OF STROKE / TRANSLATIONAL MEDICINE P1083 - ESOC25-2127 THROMBOEMBOLIC STROKE ALTERS CLAUDIN-5 ISOFORM EXPRESSION CORRELATING TO INCREASED CEREBRAL INFARCT AND EDEMA AS WELL AS DECREASED NEUROLOGICAL FUNCTION Trevor Wendt 1 , Kajsa Arkelius 1 , Henrik Andersson 1 , Rayna Gonzales 2 , Saema Ansar 1 1 Lund University, Lund, Sweden, 2 University of Arizona College of Medicine - Phoenix, Phoenix, United States Background and Aims: Claudin-5, coined as the gatekeeper of neurological function, is integral in the maintenance of the blood-brain barrier (BBB)
Its antimicrobial activity is pH-dependent and completely inhibited in the presence of albumin
