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In addition, we show that knockout of P-gp from drug resistant CHO R C5 (e.g., CHO R C5 PgpA1 , and CHO R C5 PgpA3 ) cells completely reverses the collateral sensitivity of CHO R C5 cells to tamoxifen to the same level as AuxB1 or AuxB1 Pgp cells
Zinc: Cashews and other nuts, chickpeas, lentils 5 Assaf S, Kelly O
Consequently, oxidative stress acts not only as an initial trigger in vitiligo but also as a catalyst that, by generating autoantigens and inflammatory cytokines, perpetuates autoimmune responses and drives disease progression 17,46
Second, the EEG endpoint that defined the compounds activity is a population-level pattern in the recipient cortex, not a molecular readout meaning the discovery established a phenomenology, not a pathway