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The major detoxification pathway of 4HNE involves GSTs 16

Magnesium plays a role in hundreds of processes throughout the body, including: Sleep regulation Muscle relaxation Blood sugar balance Nerve signaling Stress resilience And because stress itself can deplete magnesium 12, many people end up stuck in a cycle where higher stress contributes to lower magnesium levels, which may then worsen sleep, tension, and stress tolerance

This combination logic is particularly relevant in therapy-resistant states where ferroptosis defense is upregulated

was supported by the Lundbeck Foundation (DANDRITE-R248-2016-2518)

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