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A key study showed that this intervention improved insulin sensitivity in mice, suggesting it helps restore metabolic flexibility

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5-Amino-1MQ reduces NNMT, improving fat function, inflammation, mitochondrial output, and muscle repair.[23][32] In adipocytes, it boosts NAD+ by preventing its wasteful methylation, leading to better glucose handling

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Six controlled trials in approximately 900 participants are summarized in Stier et al