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In another study, NAC supplementation had no significant effect on serum levels of sex hormone-binding globulin (SHBG), LH, FSH, LH/FSH, E2 and testosterone in PCOS patients after 12 weeks (Reference Ghomian, Khadem and Moeindarbari5,Reference Nasr9,Reference Nemati, Nemati and Taheri12,Reference Badawy, State and Abdelgawad13)